Joint Official Positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX® Executive Summary of the 2010 Position Development Conference on Interpretation and Use of FRAX® in Clinical Practice

Hans, Didier B.; Kanis, John A.; Baim, Sanford; Bilezikian, John P.; Binkley, Neil; Cauley, Jane A.; Compston, Juliet E.; Cooper, Cyrus; Dawson-Hughes, Bess; El-Hajj Fuleihan, Ghada; Leslie, William D.; Lewiecki, E. Michael; Luckey, Marjorie M.; McCloskey, Eugene V.; Papapoulos, Socrates E.; Poiana, Catalina; Rizzoli, René; FRAX® Position Development Conference Members,

doi:10.1016/j.jocd.2011.05.007

Next »Journal of Clinical Densitometry
Volume 14, Issue 3 , Pages 171-180, July 2011

Joint Official Positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX^®:

Executive Summary of the 2010 Position Development Conference on Interpretation and Use of FRAX^® in Clinical Practice

Didier B. Hans
- Department of Bone & Joint, Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland
- Address correspondence to: Didier B. Hans, Ph.D, MBA, Department of Bone & Joint, Center of Bone Diseases, Lausanne University Hospital, Lausanne 1011, Switzerland.
John A. Kanis
- WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, United Kingdom
Sanford Baim
- Division of Endocrinology, University of Miami, Miller School of Medicine, United States of America
John P. Bilezikian
- Columbia University College of Physicians and Surgeons, New York, New York, United States of America
Neil Binkley
- Osteoporosis Clinical Research Program, University of Wisconsin, Madison, WI, United States of America
Jane A. Cauley
- Department of Epidemiology, Graduate School of public Health, University of Pittsburgh, Pittsburgh, United States of America
Juliet E. Compston
- University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Cyrus Cooper
- MRC Lifecourse Epidemiology Unit, University of Southampton, and NIHR Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Sciences, University of Oxford, United Kingdom
Bess Dawson-Hughes
- Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States of America
Ghada El-Hajj Fuleihan
- WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut, Lebanon
William D. Leslie
- University of Manitoba, Winnipeg, Canada
E. Michael Lewiecki
- New Mexico Clinical Research & Osteoporosis Center, University of New Mexico School of Medicine, Albuquerque, NM, United States of America
Marjorie M. Luckey
- St. Barnabas Osteoporosis & Metabolic Bone Disease Center, Livingston, NJ, United States of America
Eugene V. McCloskey
- NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Herries Road, Sheffield, United Kingdom
Socrates E. Papapoulos
- Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, the Netherlands
Catalina Poiana
- Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
René Rizzoli
- Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
FRAX^® Position Development Conference Members
- Task Force of the FRAX^® Initiative: see “Appendix.”

Received 21 May 2011; accepted 21 May 2011.

Abstract

The International Society for Clinical Densitometry (ISCD) and the International Osteoporosis Foundation (IOF) convened the FRAX^® Position Development Conference (PDC) in Bucharest, Romania, on November 14, 2010, following a two-day joint meeting of the ISCD and IOF on the “Interpretation and Use of FRAX^® in Clinical Practice.” These three days of critical discussion and debate, led by a panel of international experts from the ISCD, IOF and dedicated task forces, have clarified a number of important issues pertaining to the interpretation and implementation of FRAX^® in clinical practice. The Official Positions resulting from the PDC are intended to enhance the quality and clinical utility of fracture risk assessment worldwide. Since the field of skeletal assessment is still evolving rapidly, some clinically important issues addressed at the PDCs are not associated with robust medical evidence. Accordingly, some Official Positions are based largely on expert opinion. Despite limitations inherent in such a process, the ISCD and IOF believe it is important to provide clinicians and technologists with the best distillation of current knowledge in the discipline of bone densitometry and provide an important focus for the scientific community to consider. This report describes the methodology and results of the ISCD-IOF PDC dedicated to FRAX^®.

Key Words: Osteoporosis - clinical risk factors, fracture probability, risk assessment, clinical risk factors, bone mineral density, official positions, standards, world-wide