Journal of Clinical Densitometry
Volume 13, Issue 3 , Pages 277-282 , July 2010

Contribution of Serum Inflammatory Markers to Changes in Bone Mineral Content and Density in Postmenopausal Women: A 1-Year Investigation

  • E.R. Gertz

      Affiliations

    • US Department of Agriculture, ARS, Western Human Nutrition Research Center, Davis, CA, USA
    • ,
  • N.E. Silverman

      Affiliations

    • Department of Nutrition, University of California, Davis, CA, USA
    • ,
  • K.S. Wise

      Affiliations

    • Department of Nutrition, University of California, Davis, CA, USA
    • ,
  • K.B. Hanson

      Affiliations

    • Department of Food Science and Human Nutrition, Nutrition and Wellness Research Center, Iowa State University, Ames, IA, USA
    • ,
  • D.L. Alekel

      Affiliations

    • Department of Food Science and Human Nutrition, Nutrition and Wellness Research Center, Iowa State University, Ames, IA, USA
    • ,
  • J.W. Stewart

      Affiliations

    • Department of Food Science and Human Nutrition, Nutrition and Wellness Research Center, Iowa State University, Ames, IA, USA
    • ,
  • C.D. Perry

      Affiliations

    • Department of Food Science and Human Nutrition, Nutrition and Wellness Research Center, Iowa State University, Ames, IA, USA
    • ,
  • S.N. Bhupathiraju

      Affiliations

    • Department of Food Science and Human Nutrition, Nutrition and Wellness Research Center, Iowa State University, Ames, IA, USA
    • ,
  • M.L. Kohut

      Affiliations

    • Department of Kinesiology, Nutrition and Wellness Research Center, Iowa State University, Ames, IA, USA
    • ,
  • M.D. Van Loan

      Affiliations

    • Corresponding Author InformationAddress correspondence to: M. D. Van Loan, PhD, US Department of Agriculture, ARS, Western Human Nutrition Research Center, 430 West Health Sciences Center, Davis, CA 95616, USA.
    • US Department of Agriculture, ARS, Western Human Nutrition Research Center, Davis, CA, USA

Received 28 December 2009 ,Revised 17 February 2010 ,Accepted 14 April 2010.

References 

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  9. Alekel DL, Van Loan MD, Koehler KJ, et al. Soy Isoflavones for Reducing Bone Loss (SIRBL) study: three-year randomized controlled trial in postmenopausal women. Am J Clin Nutr. 2010;91:218–230
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  11. Tomiyama H, Okazaki R, Koji Y, et al. Elevated C-reactive protein: a common marker for atherosclerotic cardiovascular risk and subclinical stages of pulmonary dysfunction and osteopenia in a healthy population. Atherosclerosis. 2005;178:187–192
  12. Ganesan K, Teklehaimanot S, Tran TH, et al. Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc. 2005;97:329–333
  13. Koh JM, Khang YH, Jung CH, et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int. 2005;16:1263–1271
  14. Perry CD, Alekel DL, Ritland LM, et al. Centrally located body fat is related to inflammatory markers in healthy postmenopausal women. Menopause. 2008;15:619–627
  15. Pacifici R, Brown C, Puscheck E, et al. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA. 1991;88:5134–5138[PubMed: 2052592]
  16. Ushiroyama T, Ikeda A, Ueki M. Elevated plasma interleukin-6 (IL-6) and soluble IL-6 receptor concentrations in menopausal women with and without depression. Int J Gynaecol Obstet. 2002;79:51–52[PubMed: 12399096]

 Trial registration: NIH clinicaltrials.gov Identifier: NCT00043745.

PII: S1094-6950(10)00176-9

doi: 10.1016/j.jocd.2010.04.003

Journal of Clinical Densitometry
Volume 13, Issue 3 , Pages 277-282 , July 2010

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