Journal of Clinical Densitometry
Volume 13, Issue 2 , Pages 219-227 , April 2010

Cortical Thickness and Medullary Canal Dimensions of the Bone Phalanx Are Predicted by Quantitative Ultrasound Parameters

  • Giuseppe Guglielmi

      Affiliations

    • Department of Radiology, University of Foggia, Foggia, Italy
    • Department of Radiology, Scientific Institute Hospital “Casa Sollievo della Sofferenza,” San Giovanni Rotondo, Foggia, Puglia, Italy
    • Corresponding Author InformationAddress correspondence to: Giuseppe Guglielmi, MD, Department of Radiology, University of Foggia, Viale Luigi Pinto 1, Foggia 71100, Italy.
  • ,
  • Francesca de Terlizzi

      Affiliations

    • Scientific Department IGEA S.P.A. Biophysics Laboratory, Carpi, Modena, Italy
  • ,
  • Giacomo Scalzo

      Affiliations

    • Department of Radiology, University of Foggia, Foggia, Italy
  • ,
  • Claudia Battista

      Affiliations

    • Division of Endocrinology, Scientific Institute Hospital “Casa Sollievo della Sofferenza,” San Giovanni Rotondo, Foggia, Puglia, Italy
  • ,
  • Alfredo Scillitani

      Affiliations

    • Division of Endocrinology, Scientific Institute Hospital “Casa Sollievo della Sofferenza,” San Giovanni Rotondo, Foggia, Puglia, Italy

Received 26 August 2009 ,Revised 26 November 2009 ,Accepted 1 January 2010.

References 

  1. Bauer DC, Gluer CC, Cauley JA, et al. Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med. 1997;157:629–664
  2. Cullum ID, Ell PJ, Ryder JP. X-ray dual-photon absorptiometry: a new method for the measurement of bone density. Br J Radiol. 1989;62:587–592
  3. Ashman RB, Rho JY. Elastic modulus of trabecular bone material. J Biomech. 1988;21:177–181
  4. Bonfield W, Tully AE. Ultrasonic analysis of the Young's modulus of cortical bone. J Biomed Eng. 1982;4:23–27
  5. Njeh CF, Fuerst T, Diessel E, Genant HK. Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int. 2001;12:1–15
  6. Cavani F, Fini M, de Terlizzi F, et al. Effect of trabecular orientation on mechanical resistance and ultrasound propagation in specimens of equine vertebrae. Ultrasound Med Biol. 2003;29:1777–1785
  7. Sakata S, Barkmann R, Lochmüller EM, et al. Assessing bone status beyond bone mineral density: evaluation of bone geometry and porosity by quantitative ultrasound of human finger phalanges. J Bone Miner Res. 2004;19:924–930
  8. Wuster C, de Terlizzi F, Becker S, et al. Usefulness of quantitative ultrasound in evaluating structural and mechanical properties of bone: comparison of ultrasound, dual-energy X-ray absorptiometry, micro-computed tomography, and mechanical testing of human phalanges in vitro. Technol Health Care. 2005;13:1–14
  9. Cavani F, Giavaresi G, Fini M, et al. Influence of density, elasticity, and structure on ultrasound transmission through trabecular bone cylinders. IEEE Trans Ultrason Ferroelectr Freq Control. 2008;55:1465–1472
  10. Guglielmi G, Njeh CF, de Terlizzi F. Phalangeal quantitative ultrasound, phalangeal morphometric variables, and vertebral fracture discrimination. Calcif Tissue Int. 2003;72:469–477
  11. Parfitt AM. A structural approach to renal bone disease. J Bone Miner Res. 1998;13:1213–1220
  12. Buckwalter JA, Glimcher MJ, Cooper RR, et al. Bone biology; Part I and Part II. J Bone Joint Surg Am. 1995;8:1256–1289
  13. Biot MA. Generalized theory of acoustic propagation in porous dissipative media. J Acoust Soc Am. 1962;34:1254–1264
  14. Haïat G, Padilla F, Peyrin F, Laugier P. Variation of ultrasonic parameters with microstructure and material properties of trabecular bone: a 3D model simulation. J Bone Miner Res. 2007;22:665–674
  15. Sasso M, Haïat G, Yamato Y, et al. Frequency dependence of ultrasonic attenuation in bovine cortical bone: an in vitro study. Ultrasound Med Biol. 2007;33:1933–1942
  16. de Terlizzi F, Battista S, Cavani F, et al. Influence of bone tissue density and elasticity on ultrasound propagation: an in vitro study. J Bone Miner Res. 2000;15:2458–2466
  17. Hans D, Wu C, Njeh CF, et al. Ultrasound velocity of trabecular cubes reflects mainly bone density and elasticity. Calcif Tissue Int. 1999;64:18–23
  18. Hosokawa A, Otani T. Ultrasonic wave propagation in bovine cancellous bone. J Acoust Soc Am. 1997;101:558–562
  19. Nicholson PHF, Muller R, Lowet G, et al. Do quantitative ultrasound measurements reflect structure independently of density in human vertebral cancellous bone?. Bone. 1998;23:425–431
  20. Van den Bergh JPW, van Lenthe GH, Hermus ARMM, et al. Speed of sound reflects Young's modulus as assessed by microstructural finite elements analysis. Bone. 2000;26:519–524
  21. Evans JA, Tavakoli MB. Ultrasonic attenuation and velocity in bone. Phys Med Biol. 1990;10:1387–1396
  22. Nicholson PHF, Haddaway MJ, Davie MWJ. The dependence of ultrasonic properties on orientation in human vertebral bone. Phys Med Biol. 1994;39:1013–1024
  23. Wu C, Gluer C, Lu Y, et al. Ultrasound characterization of bone demineralization. Calcif Tissue Int. 1998;62:133–139
  24. Nicholson PHF, Bouxsein ML. Quantitative ultrasound does not reflect mechanically induced damage in human cancellous bone. J Bone Miner Res. 2000;15:2467–2472
  25. Cadossi R, de Terlizzi F, Canè V, et al. Assessment of bone architecture with ultrasonometry: experimental and clinical experience. Horm Res. 2000;54(S1):9–18
  26. Cadossi R, Canè V. Pathways of transmission of ultrasound energy through the distal metaphysis of the second phalanx of pigs: an in vitro study. Osteoporos Int. 1996;6:196–206
  27. Luisetto G, Camozzi V, de Terlizzi F. Use of quantitative ultrasonography in differentiating osteomalacia from osteoporosis: preliminary study. J Ultrasound Med. 2000;19:251–256
  28. Luisetto G, Camozzi V, de Terlizzi F, et al. Use of ultrasonography in the diagnosis of osteomalacia: preliminary results on experimental osteomalacia in the rat. J Ultrasound Med. 1999;18:225–229
  29. Kleerekoper M, Nelson DA, Flynn MJ, et al. Comparison of radiologic absorptiometry with dual energy X-ray absorptiometry and quantitative computed tomography in normal older white and black women. J Bone Miner Res. 1994;9:1745–1750
  30. Mussolino ME, Looker AC, Madans JH, et al. Phalangeal bone density and hip fracture risk. Arch Intern Med. 1997;157:433–438
  31. Buckwalter JA. Bone biology. J Bone Joint Surg. 1995;A77:1256–1289
  32. Barkmann R, Lusse S, Stampa B, et al. Assessment of the geometry of human finger phalanges using quantitative ultrasound in vivo. Osteoporos Int. 2000;11:745–755
  33. Wuster C, Albanese C, De Aloysio D, et al. Phalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. The Phalangeal Osteosonogrammetry Study Group. J Bone Miner Res. 2000;15:1603–1614
  34. Cann CE, Genant HK. Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr. 1980;4:493–500
  35. Gluer CC, Blake G, Lu Y, et al. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int. 1995;5:262–270
  36. Guglielmi G, Cammisa M, De Serio A, et al. Phalangeal US velocity discriminates between normal and vertebrally fractured subjects. Eur Radiol. 1999;9:1632–1637
  37. Chiodini I, Morelli V, Masserini B, et al. Bone mineral density, prevalence of vertebral fracture, and bone quality in patients with adrenal incidentalomas with and without subclinical hypercortisolism: an Italian multicenter study. J Clin Endocrinol Metab. 2009;94:3207–3214
  38. Guglielmi G, De Serio A, Fusilli S, et al. Age-related changes assessed by peripheral QCT in healthy Italian women. Eur Radiol. 2000;10:609–614
  39. Njeh CF, Richards A, Boivin CM, et al. Factors influencing the speed of sound through the proximal phalanges. J Clin Densitom. 1999;2:241–249
  40. Baroncelli GI. Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance, and clinical application. Pediatr Res. 2008;63:220–228
  41. Montagnani A, Gonnelli S, Cepollaro C, et al. Graphic trace analysis of ultrasound at the phalanges may differentiate between subjects with primary hyperparathyroidism and with osteoporosis: a pilot study. Osteoporos Int. 2000;13:222–227
  42. Ingle BM, Machado AB, Pereda CA, et al. Monitoring alendronate and estradiol therapy with quantitative ultrasound and bone mineral density. J Clin Densitom. 2005;8:278–286

PII: S1094-6950(10)00003-X

doi: 10.1016/j.jocd.2010.01.002

Journal of Clinical Densitometry
Volume 13, Issue 2 , Pages 219-227 , April 2010