A Comparative Study Between Corresponding Structural Geometric Variables Using 2 Commonly Implemented Hip Structural Analysis Algorithms Applied to Dual-Energy X-Ray Absorptiometry Images

Khoo, Benjamin C.C.; Wilson, Scott G.; Worth, Graeme K.; Perks, Ursula; Qweitin, Emad; Spector, Timothy D.; Price, Roger I.

doi:10.1016/j.jocd.2009.08.004

« Previous Next »Journal of Clinical Densitometry
Volume 12, Issue 4 , Pages 461-467, October 2009

A Comparative Study Between Corresponding Structural Geometric Variables Using 2 Commonly Implemented Hip Structural Analysis Algorithms Applied to Dual-Energy X-Ray Absorptiometry Images

Benjamin C.C. Khoo
- Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Scott G. Wilson
- Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
- School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia
- Department of Twin Research, St Thomas' Campus, King's College London, London, UK
Graeme K. Worth
- Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Ursula Perks
- Department of Twin Research, St Thomas' Campus, King's College London, London, UK
Emad Qweitin
- Department of Twin Research, St Thomas' Campus, King's College London, London, UK
Timothy D. Spector
- Department of Twin Research, St Thomas' Campus, King's College London, London, UK
Roger I. Price
- Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
- School of Surgery, University of Western Australia, Nedlands, Western Australia, Australia
- Address correspondence to: Roger I. Price, PhD, Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, Western Australia, Australia.

Received 20 May 2009; received in revised form 27 August 2009; accepted 27 August 2009.

Abstract

Hip structural analysis (HSA) has been developed over 20yr, applied extensively in research, and has demonstrated useful outcomes associating bone structural geometry with bone fragility (research-HSA or r-HSA). In 2007, Hologic Inc. (Bedford, MA) incorporated HSA with some modifications as an option for Hologic dual-energy X-ray absorptiometry (DXA) scanners (clinical HSA or c-HSA). This brought HSA from the research environment into the clinical environment. This article reports a comparison of r-HSA and c-HSA implementations using DXA scans from a group of 191 females. Bland-Altman plots at the narrow-neck (NN) HSA region indicated higher r-HSA areal bone mineral density (mean difference: 0.27g/cm²; 21.7% [of mean]); cross-sectional area (0.63cm²; 18.7%); cross-sectional moment of inertia (0.26cm⁴; 11.1%), and section modulus (0.22cm³; 14.5%) compared with c-HSA. The converse was observed for NN subperiosteal width (−0.09cm; 3.1%). High linear correlations (r²>0.81) were found between r-HSA and c-HSA NN structural geometric outcomes, with the exception of neck shaft angle (r²>0.47). As differences were significant (p<0.001), slopes and intercepts are provided to enable linear transformations from r-HSA to corresponding c-HSA structural geometric data.