Journal of Clinical Densitometry
Volume 12, Issue 4 , Pages 413-416 , October 2009

Beyond FRAX®: It's Time to Consider “Sarco-Osteopenia”

  • Neil Binkley

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Neil Binkley, MD, University of Wisconsin Osteoporosis Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705.
  • ,
  • Bjoern Buehring

Received 19 May 2009 ,Revised 10 June 2009 ,Accepted 18 June 2009.

References 

  1. Cooper C, Melton LJ. Epidemiology of osteoporosis. Trends Endocrinol Metab. 1992;3:224–229
  2. Morley JE. Sarcopenia: diagnosis and treatment. J Nutr Health Aging. 2008;12:452–456
  3. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50(5):889–896
  4. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997;127(5 Suppl):990S–991S
  5. Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147(8):755–763
  6. Newman AB, Kupelian V, Visser M, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51:1602–1609
  7. Delmonico MJ, Harris TB, Lee JS, et al. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55:769–774
  8. Rolland Y, Czerwinski S, Abellan Van Kan G, et al. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging. 2008;12:433–450
  9. Seeman E, Delmas P. Bone quality—the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354:2250–2261
  10. Metter EJ, Conwit R, Tobin J, Fozard JL. Age-associated loss of power and strength in the upper extremities in women and men. J Gerontol A Biol Sci Med Sci. 1997;52A:B267–B276
  11. Goodpaster BH, Park SW, Harris TB, et al. The loss of skeletal muscle strength, mass and quality in older adults: the health aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61A:1059–1064
  12. Bean JF, Leveille SG, Kiely DK, et al. A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more?. J Gerontol A Biol Sci Med Sci. 2003;58A:728–733
  13. Cesari M, Kritchevsky SB, Newman AB, et al. Added value of physical performance measures in predicting adverse health-related events: results from the health, aging and body composition study. J Am Geriatr Soc. 2009;57:251–259
  14. Guralnik JM, Ferrucci L, Pieper CF, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci. 2000;55(4):M221–M231
  15. Newman AB, Kupelian V, Visser M, et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci. 2006;61:72–77
  16. Waters DL, Mullins PG, Qualls CR, et al. Mitochondrial function in physically active elders with sarcopenia. Mech Ageing Dev. 2009;130:315–319
  17. Hakkinen K, Kraemer WJ, Newton RU, Alen M. Changes in electromyographic activity, muscle fibre and force production characteristics during heavy resistance/power strength training in middle-aged and older men and women. Acta Physiol Scand. 2001;171:51–62
  18. Hakkinen K, Kraemer WJ, Kallinen M, et al. Bilateral and unilateral neuromuscular function and muscle cross-sectional area in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci. 1996;51A:B21–B29
  19. Goodpaster B, Chomentowski P, Ward BK, et al. Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial. J Appl Physiol. 2008;105:1498–1503
  20. Burr DB. Muscle strength, bone mass, and age-related bone loss. J Bone Miner Res. 1997;12:1547–1551
  21. Proctor DN, Melton LJI, Khosla S, et al. Relative influence of physical activity, muscle mass and strength on bone density. Osteoporos Int. 2000;11:944–952
  22. Khosla S, Atkinson EJ, Riggs BL, Melton LJI. Relationship between body composition and bone mass in women. J Bone Miner Res. 1996;11:857–863
  23. Cauley JA, Danielson ME, Boudreau RM, et al. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition study. J Bone Miner Res. 2007;22:1088–1095
  24. Wicherts IS, van Schoor NM, Boeke AJP, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab. 2007;92:2058–2065
  25. Lang T, Koyama A, Li C, et al. Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture. Bone. 2008;42:798–805

PII: S1094-6950(09)00154-1

doi: 10.1016/j.jocd.2009.06.004

Journal of Clinical Densitometry
Volume 12, Issue 4 , Pages 413-416 , October 2009