Journal of Clinical Densitometry
Volume 12, Issue 3 , Pages 299-305 , July 2009

Correcting for Fat Mass Improves DXA Quantification of Quadriceps Specific Strength in Obese Adults Aged 50–59 Years

  • Neil A. Segal

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Neil A. Segal, MD, MS, Department of Orthopaedics & Rehabilitation, 200 Hawkins Drive, 0728 JPP, Iowa City, IA 52242-1088.
    • Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA
    • VA Medical Center, Iowa City, IA
    • ,
  • Natalie A. Glass

      Affiliations

    • Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA
    • ,
  • Jennifer L. Baker

      Affiliations

    • Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA
    • ,
  • James C. Torner

      Affiliations

    • Department of Epidemiology, The University of Iowa, Iowa City, IA

Received 3 October 2008 ,Revised 12 November 2008 ,Accepted 12 November 2008.

References 

  1. Newman AB, Haggerty CL, Goodpaster B, et al. Strength and muscle quality in a well-functioning cohort of older adults: the health, aging and body composition study. J Am Geriatr Soc. 2003;51:323–330
  2. Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in new Mexico. Am J Epidemiol. 1998;147:755–763
  3. Lauretani F, Russo CR, Bandinelli S, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003;95:1851–1860
  4. Melton LJ, Khosla S, Crowson CS, et al. Epidemiology of sarcopenia. J Am Geriatr Soc. 2000;48:625–630
  5. Visser M, Kritchevsky SB, Goodpaster BH, et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc. 2002;50:897–904
  6. Visser M, Goodpaster BH, Kritchevsky SB, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci. 2005;60:324–333
  7. Mitsiopoulos N, Baumgartner RN, Heymsfield SB, et al. Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol. 1998;85:115–122
  8. Goodpaster BH, Thaete FL, Kelley DE. Composition of skeletal muscle evaluated with computed tomography. Ann N Y Acad Sci. 2000;904:18–24
  9. Levine JA, Abboud L, Barry M, et al. Measuring leg muscle and fat mass in humans: comparison of ct and dual-energy X-ray absorptiometry. J Appl Physiol. 2000;88:452–456
  10. Visser M, Fuerst T, Lang T, et al. Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, aging, and body composition study—Dual-energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol. 1999;87:1513–1520
  11. Wang ZM, Visser M, Ma R, et al. Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods. J Appl Physiol. 1996;80:824–831
  12. Proctor DN, O'Brien PC, Atkinson EJ, Nair KS. Comparison of techniques to estimate total body skeletal muscle mass in people of different age groups. Am J Physiol. 1999;277:E489–E495
  13. Kim J, Wang Z, Heymsfield SB, et al. Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr. 2002;76:378–383
  14. National Center for Health Statistics . Health, United States with chartbook on trends in the health of Americans. Maryland: U.S. Government Printing Office; 2005;
  15. Segal NA, Torner JC, Yang M. Muscle mass is more strongly related to hip bone mineral density than is quadriceps strength or lower activity level in adults over age 50 years. J Clin Densitom. 2008;11:1–8
  16. Goodpaster BH, Carlson CL, Visser M, et al. Attenuation of skeletal muscle and strength in the elderly: the health ABC study. J Appl Physiol. 2001;90:2157–2165
  17. Newman AB, Kupelian V, Visser M, et al. Sarcopenia: Alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51:1602–1609
  18. Fuller NJ, Laskey MA, Elia M. Assessment of the composition of major body regions by dual-energy X-ray absorptiometry (DEXA), with special reference to limb muscle mass. Clin Physiol. 1992;12:253–266
  19. Fuller NJ, Hardingham CR, Graves M, et al. Assessment of limb muscle and adipose tissue by dual-energy X-ray absorptiometry using magnetic resonance imaging for comparison. Int J Obes Relat Metab Disord. 1999;23:1295–1302

 Funding: This work was funded by NICHD through the Association of Academic Physiatrists (Neil Segal, MD—5K12HD001097-08).Disclaimers: The authors have no professional relationships with companies or manufacturers who will benefit from the results of the present study.

PII: S1094-6950(08)00503-9

doi: 10.1016/j.jocd.2008.11.003

Journal of Clinical Densitometry
Volume 12, Issue 3 , Pages 299-305 , July 2009

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