Age-Related Trends in Phalangeal Bone Mineral Density in Sri Lankan Men and Women Aged 20 Years or More

Abstract 

To establish normative reference values and to study the age-related trends in phalangeal bone mineral density (BMD), 4504 male and 5215 female volunteers aged 20yr or more were recruited from 7 provinces from October 2004 to October 2005. Subjects suffering from diseases and those who were taking medications, which could affect BMD were excluded from the analysis (n=530). Phalangeal BMD was measured in the nondominant hand using an AccuDXA. Men and women were categorized to age groups of 20–29 (1087 men and 1079 women), 30–39 (1122 men and 1146 women), 40–49 (1148 men and 1455 women), 50–59 (810 men and 1111 women), 60–69 (250 men and 335 women), and 70yr or more (87 men and 94 women). Mean BMDs (SD) of men in above categories were 0.595 (0.057), 0.603 (0.061), 0.591 (0.066), 0.576 (0.069), 0.558 (0.077), and 0.522 (0.079)g/cm², respectively. The corresponding BMDs (SD) in women were 0.495 (0.057), 0.506 (0.062), 0.502 (0.064), 0.462 (0.072), 0.406 (0.072), and 0.340 (0.055)g/cm², respectively. Peak BMD was seen in 30–39-age category in both sexes. Women after 50yr lost BMD at a rate of 0.006 (standard error 0.0003)g/cm²/yr, whereas the corresponding value in men was 0.002 (standard error 0.0001)g/cm²/yr. These data provide normative reference data for the calculation of T-score and Z-score for phalangeal BMD in Sri Lankan men and women aged more than 20yr.

Key Words: AccuDXA, osteoporosis, phalangeal bone mineral density, reference data, Sri Lanka