Bone Mineral Density in Premenopausal Arab Women With Type 2 Diabetes Mellitus

Gupta, Renu; Mohammed, Ahmed M.; Mojiminiyi, Olusegun A.; Alenizi, Eman K.; Abdulla, Nabila A.

doi:10.1016/j.jocd.2008.09.003

« Previous Next »Journal of Clinical Densitometry
Volume 12, Issue 1 , Pages 54-57, January 2009

Bone Mineral Density in Premenopausal Arab Women With Type 2 Diabetes Mellitus

Renu Gupta
- Department of Radiology, Faculty of Medicine, Kuwait University, Kuwait
- Department of Radiology, Mubarak Al-Kabeer Hospital, Kuwait
- Address correspondence to: R. Gupta, MD, Department of Radiology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait.
Ahmed M. Mohammed
- Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait
- Department of Nuclear Medicine, Farwania Hospital, Kuwait
Olusegun A. Mojiminiyi
- Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
- Department of Pathology, Mubarak Al-Kabeer Hospital, Kuwait
Eman K. Alenizi
- Department of Nuclear Medicine, Mubarak Al-Kabeer Hospital, Kuwait
Nabila A. Abdulla
- Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait
- Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait

Received 2 August 2008; received in revised form 8 September 2008; accepted 19 September 2008. published online 12 November 2008.

Abstract

Introduction

This study compares an ethnically uniform group of premenopausal type 2 diabetic (T2DM) Arab women with a matched control group of nondiabetic subjects, in terms of their bone mineral density (BMD) and anthropometric measurements.

Methods

The study included 252 premenopausal Arab women. Their age ranged from 26 to 50yr with a mean±SD of 43.65±8.97yr. One hundred and twenty-two women were T2DM patients and 130 women were nondiabetic controls. The controls matched the subjects in gender, age, and body mass index (BMI). BMD was measured at total lumbar spine (L1–L4) and total left hip, using dual-energy X-ray absorptiometry (DXA; HOLOGIC, QRS SERIES, Europe, Belgium). Difference in BMD and its relationship to the anthropometric measurements in T2DM and control groups were assessed.

Results

Significant difference was found between T2DM patients and nondiabetic patients in their mean hip BMD (0.92±0.16 vs. 0.87±0.14, p<0.05) and spine BMD (0.93±0.15 vs. 0.88±0.14, p<0.01). No significant difference was found in age, height, weight, and BMI (p>0.05). The increase in hip BMD in T2DM patients normalized and the increase in spine BMD persisted after controlling for the confounding effect of age and anthropometric measurements.

Conclusion

Premenopausal Arab women with T2DM have higher BMD at the spine than women without T2DM. The underlying mechanism causing this increase does not seem to be related to ethnicity, gender, hormonal status, or anthropometric measurements.

Key Words: Bone mineral density, premenopausal women, type 2 diabetes mellitus