The Effect of Peritoneal Dialysate on DXA Bone Densitometry Results in Patients with End-Stage Renal Disease

Mann, Merry Lynn; Thornley-Brown, Denyse; Campbell, Ruth; Bell, Emmy; Burroughs, Leandria; Nunnally, Nancy; Feng, Rui; Morgan, Sarah L.

doi:10.1016/j.jocd.2008.08.103

« Previous Next »Journal of Clinical Densitometry
Volume 11, Issue 4 , Pages 532-536, October 2008

The Effect of Peritoneal Dialysate on DXA Bone Densitometry Results in Patients with End-Stage Renal Disease

Merry Lynn Mann, BS
- University of Alabama at Birmingham (UAB) School of Medicine, Birmingham, AL, USA
Denyse Thornley-Brown, MD
- Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
Ruth Campbell, MD
- Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
Emmy Bell, MD
- Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
Leandria Burroughs, RT (R), CDT
- The UAB Osteoporosis Prevention and Treatment Clinic, The Kirklin Clinic, The University of Alabama at Birmingham, Birmingham, AL, USA
Nancy Nunnally, RT(R), CDT
- The UAB Osteoporosis Prevention and Treatment Clinic, The Kirklin Clinic, The University of Alabama at Birmingham, Birmingham, AL, USA
Rui Feng, PhD
- Department of Biostatistics, School of Public Health, The University of Alabama at Birmingham, Birmingham, AL, USA
Sarah L. Morgan, MD, MS, RD, CCD, FADA, FACP
- The UAB Osteoporosis Prevention and Treatment Clinic, The Kirklin Clinic, The University of Alabama at Birmingham, Birmingham, AL, USA
- Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL, USA
- Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
- Address correspondence to: Sarah L. Morgan, MD, MS, RD, CCD, FADA, FACP, Departments of Nutrition Sciences and Medicine, The University of Alabama at Birmingham, 354 Learning Resources Center, 1714 9th Avenue South, Birmingham, AL 35294-1270.

Received 7 May 2008; accepted 11 August 2008. published online 22 September 2008.

Abstract

The bone mineral density of patients undergoing peritoneal dialysis (PD) is low compared to a healthy population. No studies have been conducted to investigate whether the presence of peritoneal dialysate affects dual-energy X-ray absorptiometry (DXA) results. We hypothesized that the presence of peritoneal dialysate would not affect the measurement of bone mineral density (BMD) or bone mineral content (BMC) in the spine. Thirty patients on PD had DXA scans of the lumbar spine and hip completed before and after the drainage of peritoneal dialysate. A paired t-test was used to compare the difference in area, BMC, and BMD before and after drainage of dialysate. A significant difference was found in the BMC of the spine before and after the drainage of dialyzate. We recommend that peritoneal dialyzate be removed prior to scanning patients on PD and that densitometry technologists should be observant about the presence of peritoneal dialysate.

Key Words: Bone mineral content, bone mineral density, end-stage kidney disease, peritoneal dialysis