Journal of Clinical Densitometry
Volume 11, Issue 4 , Pages 537-542 , October 2008

Bone Mineral Density in Cystic Fibrosis: Benefit of Exercise Capacity

  • Jonathan D. Dodd

      Affiliations

    • Department of Radiology, St. Vincent's University Hospital, Dublin, Ireland
    • Corresponding Author InformationAddress correspondence to: Jonathan Dodd, MD, MSc, MRCPI, FFR(RCSI), Department of Radiology, St. Vincent's University Hospital, Elm Park, Dublin, Dublin 4, Ireland.
  • ,
  • Sinead C. Barry

      Affiliations

    • Department of Respiratory Medicine and National Referral Center for Adult Cystic Fibrosis, St. Vincent's University Hospital, Dublin, Ireland
  • ,
  • Rupert B.M. Barry

      Affiliations

    • Department of Respiratory Medicine and National Referral Center for Adult Cystic Fibrosis, St. Vincent's University Hospital, Dublin, Ireland
  • ,
  • Tom. J. Cawood

      Affiliations

    • Department of Endocrinology and DXA Unit, St. Vincent's University Hospital, Dublin, Ireland
  • ,
  • Malachi J. McKenna

      Affiliations

    • Department of Endocrinology and DXA Unit, St. Vincent's University Hospital, Dublin, Ireland
  • ,
  • Charles G. Gallagher

      Affiliations

    • Department of Respiratory Medicine and National Referral Center for Adult Cystic Fibrosis, St. Vincent's University Hospital, Dublin, Ireland

Received 10 October 2007 ,Revised 14 May 2008 ,Accepted 15 May 2008.

References 

  1. Hanly JG, McKenna MJ, Quigley C, et al. Hypovitaminosis D and response to supplementation in older patients with cystic fibrosis. Q J Med. 1985;56:377–385
  2. Haworth CS, Selby PL, Webb AK, et al. Low bone mineral density in adults with cystic fibrosis. Thorax. 1999;54:961–967
  3. Laursen EM, Molgaard C, Michaelsen KF, et al. Bone mineral status in 134 patients with cystic fibrosis. Arch Dis Child. 1999;81:235–240
  4. Rossini M, Del Marco A, Dal Santo F, et al. Prevalence and correlates of vertebral fractures in adults with cystic fibrosis. Bone. 2004;35:771–776
  5. Elkin SL, Fairney A, Burnett S, et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int. 2001;12:366–372
  6. Conway SP, Morton AM, Oldroyd B, et al. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax. 2000;55:798–804
  7. Cawood TJ, McKenna MJ, Gallagher CG, et al. Oral bisphosphonates improve bone mineral density in adults with cystic fibrosis. Ir Med J. 2005;98:270–273
  8. Donovan DS, Papadopoulos A, Staron RB, et al. Bone mass and vitamin D deficiency in adults with advanced cystic fibrosis lung disease. Am J Respir Crit Care Med. 1998;157:1892–1899
  9. Shane E, Silverberg SJ, Donovan D, et al. Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. [see comments] Am J Med. 1996;101:262–269
  10. Bachrach LK, Loutit CW, Moss RB. Osteopenia in adults with cystic fibrosis. [see comments] Am J Med. 1994;96:27–34
  11. Henderson RC, Madsen CD. Bone density in children and adolescents with cystic fibrosis. J Pediatr. 1996;128:28–34
  12. Buntain HM, Greer RM, Schluter PJ, et al. Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax. 2004;59:149–155
  13. Aris RM, Ontjes DA, Buell HE, et al. Abnormal bone turnover in cystic fibrosis adults. Osteoporos Int. 2002;13:151–157
  14. Aris RM, Renner JB, Winders AD, et al. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med. 1998;128:186–193
  15. Conway SP. Impact of lung inflammation on bone metabolism in adolescents with cystic fibrosis. Paediatr Respir Rev. 2001;2:324–331
  16. King SJ, Topliss DJ, Kotsimbos T, et al. Reduced bone density in cystic fibrosis: ▵F508 mutation is an independent risk factor. Eur Respir J. 2005;25:54–61
  17. Grey AB, Ames RW, Matthews RD, et al. Bone mineral density and body composition in adult patients with cystic fibrosis. Thorax. 1993;48:589–593
  18. Greendale GA, Barrett-Connor E, Edelstein S, et al. Lifetime leisure exercise and osteoporosis. The Rancho Bernardo study. Am J Epidemiol. 1995;141:951–959
  19. Frangolias DD, Pare PD, Kendler DL, et al. Role of exercise and nutrition status on bone mineral density in cystic fibrosis. J Cyst Fibros. 2003;2:163–170
  20. Looker AC, Wahner HW, Dunn WL, et al. Proximal femur bone mineral levels of US adults. Osteoporos Int. 1995;5:389–409
  21. The international society for clinical densitometry, Official positions. Available at: http://www.iscd.org/Visitors/positions/OfficialPositionsText.cfm. Accessed October 4, 2008.
  22. American Thoracic Society . Standardization of spirometry, 1994 update. Am J Respir Crit Care Med. 1995;152(3):1107–1136
  23. McKone EF, Barry SC, FitzGerald MX, Gallagher CG. Reproducibility of maximal exercise ergometer testing in patients with cystic fibrosis. Chest. 1999;116:363–368
  24. ATS/ACCP . ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003;167:211–277
  25. Jones N. Clinical exercise testing. 3rd ed.. Philadelphia, PA: Saunders; 1988;pp. 289–311
  26. Wasserman K HJ, Sue DY. Principles of exercise testing and interpretation. 2nd ed.. Philadelphia, PA: Lea and Febiger; 1987;pp. 454–463
  27. Magkos F, Yannakoulia M, Kavouras SA, et al. The type and intensity of exercise have independent and additive effects on bone mineral density. Int J Sports Med. 2007;28:773–779
  28. Korpelainen R, Keinanen-Kiukaanniemi S, Heikkinen J, et al. Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention. Osteoporos Int. 2006;17:109–118
  29. Enright S, Chatham K, Ionescu AA, et al. Inspiratory muscle training improves lung function and exercise capacity in adults with cystic fibrosis. Chest. 2004;126:405–411
  30. Strauss GD, Osher A, Wang CI, et al. Variable weight training in cystic fibrosis. Chest. 1987;92:273–276
  31. Selvadurai HC, Blimkie CJ, Meyers N, et al. Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol. 2002;33:194–200
  32. Jorgensen NR, Schwarz P, Holme I, et al. The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease: a cross sectional study. Respir Med. 2007;101:177–185
  33. Katsura H, Kida K. A comparison of bone mineral density in elderly female patients with COPD and bronchial asthma. Chest. 2002;122:1949–1955
  34. Boyle MP, Noschese ML, Watts SL, et al. Failure of high-dose ergocalciferol to correct vitamin D deficiency in adults with cystic fibrosis. Am J Respir Crit Care Med. 2005;172:212–217
  35. Yankaskas JR, Marshall BC, Sufian B, et al. Cystic fibrosis adult care: consensus conference report. Chest. 2004;125:1S–39S
  36. Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16:713–716
  37. McKenna MJ, Freaney R. Secondary hyperparathyroidism in the elderly: means to defining hypovitaminosis D. Osteoporos Int. 1998;8(Suppl 2):S3–S6
  38. Cawood TJ, McKenna MJ, Gallagher CG, et al. Cystic fibrosis-related diabetes in adults. Ir Med J. 2006;99:83–86

PII: S1094-6950(08)00188-1

doi: 10.1016/j.jocd.2008.05.095

Journal of Clinical Densitometry
Volume 11, Issue 4 , Pages 537-542 , October 2008