Journal of Clinical Densitometry
Volume 11, Issue 1 , Pages 43-58 , January 2008

Dual Energy X-ray Absorptiometry Interpretation and Reporting in Children and Adolescents: The 2007 ISCD Pediatric Official Positions

  • Catherine M. Gordon

      Affiliations

    • Divisions of Endocrinology and Adolescent Medicine, Children's Hospital Boston, Boston, MA, USA
    • Corresponding Author InformationAddress correspondence to: Catherine M. Gordon, MD, M.Sc, Divisions of Endocrinology and Adolescent Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115.
    • Task Force Chair.
    • ,
  • Laura K. Bachrach

      Affiliations

    • Stanford University, Palo Alto, CA, USA
    • Task Force Member.
    • ,
  • Thomas O. Carpenter

      Affiliations

    • Yale University, New Haven, CT, USA
    • Task Force Member.
    • ,
  • Nicola Crabtree

      Affiliations

    • Queen Elizabeth Hospital, Birmingham, UK
    • Task Force Member.
    • ,
  • Ghada El-Hajj Fuleihan

      Affiliations

    • American University of Beirut, Beirut, Lebanon
    • Task Force Member.
    • ,
  • Stepan Kutilek

      Affiliations

    • Center for Clinical and Basic Research—Synarc, Pardubice, Czech Republic
    • Task Force Member.
    • ,
  • Roman S. Lorenc

      Affiliations

    • Children's Memorial Health Institute, Warsaw, Poland
    • Task Force Member.
    • ,
  • Laura L. Tosi

      Affiliations

    • Children's National Medical Center, Washington, DC, USA
    • Task Force Member.
    • ,
  • Katherine A. Ward

      Affiliations

    • University of Manchester, Manchester, UK
    • Task Force Member.
    • ,
  • Leanne M. Ward

      Affiliations

    • University of Ottawa, Ottawa, Canada
    • Task Force Member.
    • ,
  • Heidi J. Kalkwarf

      Affiliations

    • Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
    • Task Force Liaison.

Received 5 December 2007 ,Accepted 5 December 2007.

References 

  1. Bailey DA, Martin AD, McKay HA, et al. Calcium accretion in girls and boys during puberty: a longitudinal analysis. J Bone Miner Res. 2000;15:2245–2250
  2. Theintz G, Buchs B, Rizzoli R, et al. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab. 1992;75:1060–1065
  3. Bachrach LK. Osteoporosis and measurement of bone mass in children and adolescents. Endocrinol Metab Clin North Am. 2005;34:521–535
  4. Gordon CM. Measurement of bone density in children. Curr Opin Endocrinol Metab. 2005;12:444–451
  5. Bonjour JP, Theintz G, Buchs B, et al. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab. 1991;73:555–563
  6. Recker RR, Davies KM, Hinders SM, et al. Bone gain in young adult women. JAMA. 1992;4(268):2403–2408
  7. Lloyd T, Rollings N, Andon DB, et al. Determinants of bone density in young women. I. Relationships among pubertal development, total body bone mass, and total body bone density in premenarchal females. J Clin Endocrinol Metab. 1992;75:383–387
  8. Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int. 2000;11:985–1009
  9. Melton LJ, Kan SH, Frye MA, et al. Epidemiology of vertebral fractures in women. Am J Epidemiol. 1989;129:1000–1011
  10. Hui SL, Slemenda CW, Johnston CC. The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int. 1990;1:30–34
  11. Soyka LA, Fairfield WP, Klibanski A. Hormonal determinants and disorders of peak bone mass in children. J Clin Endocrinol Metab. 2000;85:3951–3963
  12. Roth J, Palm C, Scheuneman I, et al. Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry. Arthritis Rheum. 2004;50:1277–1285
  13. Burnham JM, Shults J, Semeao E, et al. Whole body BMC in pediatric Crohn disease: independent effects of altered growth, maturation, and body composition. J Bone Miner Res. 2004;19:1961–1968
  14. Bielinski BK, et al. Impact of disordered puberty on bone density in beta-thalassaemia major. Br J Haematol. 2003;120:353–358
  15. Rauch F, Plotkin H, Zeitlin H, et al. Bone mass, size, and density in children and adolescents with osteogenesis imperfecta: effect of intravenous pamidronate therapy. J Bone Miner Res. 2003;18:610–614
  16. Miller KK, Lee EE, Lawson EA, et al. Determinants of skeletal loss and recovery in anorexia nervosa. J Clin Endocrinol Metab. 2006;91:2931–2937
  17. Gafni RI, Baron J. Overdiganosis of osteoporosis in children due to misinterpretation of dual-energy X-ray absorptiometry (DEXA). J Pediatr. 2004;144:253–257
  18. Binkovitz LA, Henwood MJ. Pediatric DXA: technique and interpretation. Pediatr Radiol. 2007;37:21–31
  19. Fewtrell MS, British Pediatric and Adolescent Bone Group . Bone densitometry in children assessed by dual X-ray absorptiometry: uses and pitfalls. Arch Dis Child. 2003;88:795–798
  20. Arabi A, Nabulsi M, Maalouf J, et al. Bone mineral density by age, gender, pubertal stages, and socioeconomic status in healthy Lebanese children and adults. Bone. 2004;35:1169–1179
  21. Ward KA, Ashby RL, Roberts SA, et al. UK reference data for the Hologic QDR Discovery dual-energy X-ray absorptiometry scanner in healthy children and young adults aged 6–17 years. Arch Dis Child. 2007;92:53–59
  22. Cooper C, Dennison EM, Leufkens HG, et al. Epidemiology of childhood fractures in Britain: a study using the general practice research database. J Bone Miner Res. 2004;19:1976–1981
  23. Faulkner RA, Davison KW, Bailey DA, et al. Size-corrected BMD decreases during peak linear growth: implications for fracture incidence during adolescence. J Bone Miner Res. 2006;21:1864–1870
  24. Jones IE, Taylor RW, Williams SM, et al. Four-year gain in bone mineral in girls with and without past forearm fractures: a DXA study. J Bone Miner Res. 2002;17:1065–1072
  25. Goulding A, Gold E, Cannan R, et al. Changing femoral geometry in growing girls: a cross sectional DEXA study. Bone. 1996;19:645–649
  26. Goulding A, Cannan R, Williams SM, et al. Bone mineral density in girls with forearm fractures. J Bone Miner Res. 1998;13:143–148
  27. Goulding A, Jones IE, Taylor RW, et al. More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J Bone Miner Res. 2000;15:2011–2018
  28. Goulding A, Taylor RW, Jones IE, et al. Overweight and obese children have low bone mass and area for their weight. Int J Obes Relat Metab Disord. 2000;24:627–632
  29. Goulding A, Jones IE, Taylor RW, et al. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy X-ray absorptiometry study. J Pediatr. 2001;139:509–515
  30. Goulding A, Jones IE, Taylor RW, et al. Dynamic and static tests of balance and postural sway in boys: effects of previous wrist bone fractures and high adiposity. Gait Posture. 2003;17:136–141
  31. Goulding A, Rockell JE, Black RE, et al. Children who avoid drinking cow's milk are at increased risk for prepubertal bone fractures. J Am Diet Assoc. 2004;104:250–253
  32. Goulding A, Grant AM, Williams SM. Bone and body composition of children and adolescents with repeated forearm fractures. J Bone Miner Res. 2005;20:2090–2096
  33. Goulding A, Jones IE, Williams SM, et al. First fracture is associated with increased risk of new fractures during growth. J Pediatr. 2005;146:286–288
  34. Jones G, Nguyen TV. Associations between maternal peak bone mass and bone mass in prepubertal male and female children. J Bone Miner Res. 2000;15:1998–2004
  35. Jones G. Growth, children, and fractures. Curr Osteoporos Rep. 2004;2:75–78
  36. Jones G, Ma DQ. Skeletal age deviation assessed by the Tanner-Whitehouse 2 method is associated with bone mass and fracture risk in children. Bone. 2005;36:352–357
  37. Jones IE, Cannan R, Goulding A. Distal forearm fractures in New Zealand children: annual rates in a geographically defined area. N Z Med J. 2000;113:443–445
  38. Jones IE, Williams SM, Dow N, et al. How many children remain fracture-free during growth? A longitudinal study of children and adolescents participating in the Dunedin multidisciplinary health and development study. Osteoporos Int. 2002;13:990–995
  39. Jones IE, Williams SM, Goulding A. Associations of birth weight and length, childhood size, and smoking with bone fractures during growth: evidence from a birth cohort. Am J Epidemiol. 2004;159:343–350
  40. Jones G, Ma D, Cameron F. Bone density interpretation and relevance in Caucasian children aged 9–17 years of age: insights from a population-based fracture study. J Clin Densitom. 2006;9:202–209
  41. Yeh FJ, Grant AM, Williams SM, et al. Children who experience their first fracture at a young age have high rates of fracture. Osteoporos Int. 2006;17:267–272
  42. Ferrari SL, Chvalley T, Bonjour JP, et al. Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?. J Bone Miner Res. 2006;21:501–507
  43. Clark E, Ness AR, Bishop NJ, et al. Association between bone mass and fractures in children: a prospective cohort study. J Bone Miner Res. 2006;21:1489–1495
  44. Shepherd JA, Fan B, Sherman M, et al. Pediatric DXA precision varies with age. J Bone Miner Res. 2004;19:S234
  45. Johnson J, Dawson Hughes B. Precision and stability of dual-energy-X-ray absorptiometry measurements. Calcif Tissue Int. 1991;49:174–178
  46. Sievanen H, Oja P, Vuori I. Precision of dual-energy X-ray absorptiometry in determining bone mineral density and content of various skeletal sites. J Nucl Med. 1991;33:1137–1142
  47. Tothill P, Avenill A, Rein DM. Precision and accuracy of measurements of whole body bone mineral: comparisons between Hologic, Lunar, and Horland dual-energy X-ray absorptimeters. Br J Radiol. 1994;67:1210–1217
  48. Rauch F, Neu CM, Manz F, et al. The development of metaphyseal cortex - implications for distal radius fractures during growth. J Bone Miner Res. 2001;16:1547–1555
  49. Crabtree NJ, Kent K, Zemel B. Acquisition of DXA in children and adolescents. In:  Sawyer AE,  Bachrach LK,  Fung EB editor. Bone Densitometry in Growing Patients. Totowa, NJ: Humana Press; 2007;p. 81
  50. Soyka LA, Grinspoon S, Levitsky LL, et al. The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab. 1999;84:4489–4496
  51. Gordon CM, Goodman E, Emans SJ, et al. Physiologic regulators of bone turnover in young women with anorexia nervosa. J Pediatr. 2002;141:64–70
  52. Herzog D, Bishop N, Glorieux F, et al. Interpretation of bone mineral density values in pediatric Crohn's disease. Inflamm Bowel Dis. 1998;4:261–267
  53. Burnham JM, Shults J, Semcao E, et al. Body-composition alterations consistent with cachexia in children and young adults with Crohn disease. Am J Clin Nutr. 2005;82:413–420
  54. von Scheven E, et al. Variable deficits of bone mineral despite chronic glucocorticoid therapy in pediatric patients with inflammatory diseases: a Glaser Pediatric Research Network study. J Pediatr Endocrinol Metab. 2006;19:821–830
  55. Leonard MB, Feldman HI, Shults J, et al. Long-term, high-dose glucocorticoids and bone mineral content in childhood glucocorticoid-sensitive nephrotic syndrome. N Engl J Med. 2004;351:868–875
  56. Moynahan M, Betz RR, Triolo RJ, et al. Characterization of the bone mineral density of children with spinal cord injury. J Spinal Cord Med. 1996;19:249–254
  57. Tasdemir HA, Buyukavci M, Akcay F, et al. Bone mineral density in children with cerebral palsy. Pediatr Int. 2001;43:157–160
  58. Henderson RC, Lark RK, Gurka M, et al. Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy. Pediatrics. 2002;110:1–10
  59. Bianchi ML, Mazzanti A, Galbiati E, et al. Bone mineral density and bone metabolism in Duchenne muscular dystrophy. Osteoporos Int. 2003;14:761–767
  60. Tuckerman K, Hofmaste P, Rosen CJ, et al. Bone density in ambulatory and immobile children. J Clin Densitom. 2002;5:327–334
  61. Hawker GA, Ridout R, Harris VA, et al. Alendronate in the treatment of low bone mass in steroid-treated boys with Duchennes muscular dystrophy. Arch Phys Med Rehabil. 2005;86:284–288
  62. Klein GL, Herndon DN, Langman CB, et al. Long-term reduction in bone mass after severe burn injury in children. J Pediatr. 1995;126:252–256
  63. Pludowski P, Lebiedowski M, Olszaniecka M, et al. Idiopathic juvenile osteoporosis— Analysis of muscle-bone relationship. Osteoporos Int. 2006;17:1681–1690
  64. Schoenau E, Neu CM, Mokov E, et al. Influence of puberty on muscle area and cortical bone area of the forearm in boys and girls. J Clin Endocrinol Metab. 2000;85:1095–1098
  65. Crabtree NJ, Kibirige MS, Fordham JN, et al. The relationship between lean body mass and bone mineral content in pediatric health and disease. Bone. 2004;35:965–972
  66. Hogler W, Briody J, Woodhead HJ, et al. Importance of lean mass in the interpretation of total body densitometry in children and adolescents. J Pediatr. 2003;143:81–88
  67. Fricke O, Schoenau E. The 'Functional Muscle-Bone Unit': probing the relevance of mechanical signals for bone development in children and adolescents. Growth Horm IGF Res. 2007;17:1–9
  68. Taylor A, Konrad PT, Norman ME, et al. Total body bone mineral density in young children: influence of head bone mineral density. J Bone Miner Res. 1997;12:652–655
  69. McKay HA, Petit MA, Bailey DA, et al. Analysis of proximal femur DXA scans in growing children: comparisons of different protocols for cross-sectional 8-month and 7-year longitudinal data. J Bone Miner Res. 2000;15:1181–1188
  70. Kalkwarf HJ, Zemel BS, Gilsanz V, et al. The Bone Mineral Density in Childhood Study (BMDCS): bone mineral content and density according to age, sex and race. J Clin Endocrinol Metab. 2007;92:2087–2099
  71. Lu PW, Cowell C, Lloyd-Jones SA, et al. Volumetric bone mineral density in normal subjects, aged 5–27 years. J Clin Endocrinol Metab. 1996;81:1586–1590
  72. Kroger H, Kotaniemi A, Vainio P, et al. Bone densitometry of the spine and femur in children by dual-energy X-ray absorptiometry. Bone Miner. 1992;17:9–15
  73. Cromer BA, Binkovitz L, Ziegler J, et al. Reference values for bone mineral density in 12- to 18-year-old girls categorized by weight, race, and age. Pediatr Radiol. 2004;34:787–792
  74. Henderson RC, et al. Pediatric reference data for dual X-ray absorptiometric measures of normal bone density in the distal femur. Am J Roentgenol. 2002;178:439–443
  75. Van Coeverden SCCM, De Rider CM, Roos JC, et al. Pubertal maturation characteristics and the rate of bone mass development longitudinally toward menarche. J Bone Miner Res. 2001;16:774–778
  76. Ellis KJ, Shypailo RJ, Hardin DS, et al. Z-score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res. 2001;16:1658–1664
  77. Wren TA, Liu T, Pitukcheewanont P, et al. Bone acquisition in healthy children and adolescents: comparisons of DXA and CT measurements. J Clin Endocrinol Metab. 2005;90:1925–1928
  78. Clark E, Tobias JH, Ness AR. Association between bone density and fractures in children: a systematic review and meta-analysis. Pediatrics. 2006;117:291–297
  79. Gluer C, et al. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int. 1995;5:262–270
  80. Baim S, Wilson CR, Lewiecki EM, et al. Precision assessment and radiation safety for dual-energy X-ray absorptiometry. J Clin Densitom. 2005;8:371–378
  81. The Writing Group for the ISCD Position Development Conference . Diagnosis of osteoporosis in men, premenopausal women, and children. J Clin Densitom. 2004;7:17–26
  82. Koo WWK, Walters J, Bush AJ. Technical considerations of dual-energy X-ray absorptiometry-based bon mineral measurements for pediatric studies. J Bone Miner Res. 1995;10:1998–2004
  83. Margulies L, Horlick M, Thornton JC, et al. Reproducibility of pediatric whole body bone and body composition measures by dual-energy X-ray absorptiometry using the GE Lunar Prodigy. J Clin Densitom. 2005;8:298–304
  84. National Osteoporosis Society . A practical guide to bone densitometry in children. Camerton, Bath: National Osteoporosis Society; 2004;
  85. Bonnick SL, Johnston CC, Kleerekoper M, et al. Importance of precision in bone density measurements. J Clin Densitom. 2001;4:105–110
  86. Wahner HW, Fogelman I. The evaluation of osteoporosis: dual energy X-ray absorptiometry in clinical practice. Cambridge: Martin Dunitz; 1994;
  87. Abbassi V. Growth and normal puberty. Pediatrics. 1998;102:507–511
  88. Ward LM. Osteoporosis due to glucocorticoid use in children with chronic illness. Horm Res. 2005;64:209–221
  89. Ward KA, Adams JE, Freemont TJ, et al. Can bisphosphonate treatment be stopped in a growing child with skeletal fragility?. Osteoporos Int. 2007;18:1137–1140
  90. Rauch F, Munns C, Land C, et al. Pamidronate in children and adolescents with osteogenesis imperfecta: Effect of treatment discontinuation. J Clin Endocrinol Metab. 2006;91:1268–1274
  91. Wong L, Lu Y, Fan B, Winer K, et al. 2006 Monitoring time interval for BMD at different skeletal sites in children. Abstract 156, annual ISCD meeting.
  92. Molgaard C, Thomsen BL, Prentice A, et al. Whole body bone mineral content in healthy children and adolescents. Arch Dis Child. 1997;76:9–15
  93. Horlick M, Wang J, Pierson RN, et al. Prediction models for evaluation of total-body bone mass with dual-energy X-ray absorptiometry among children and adolescents. Pediatrics. 2004;114:e339–e445
  94. Skaggs DL, Loro ML, Pitukcheewanont P, et al. Increased body weight and decreased radial cross-sectional dimenstions in girls with forearm fractures. J Bone Miner Res. 2001;2001(16):1337–1342
  95. Kaste SC, Tong X, Hendrick JM, et al. QCT versus DXA in 320 survivors of childhood cancer: association of BMD with fracture history. Peditr Blood Cancer. 2006;47:936–943
  96. Fielding KT, Nix DA, Bachrach LK. Comparison of calcaneus ultrasound and dual X-ray absortiometry in children at risk for osteopenia. J Clin Densitom. 2003;6:7–15
  97. Arabi A, Tamim H, Nabulsi M, et al. Sex differences in the effect of body-composition variables on bone mass in healthy children and adolescents. Am J Clin Nutr. 2004;80:1428–1435
  98. Fewtrell MS, Gordon I, Biassoni L, et al. Dual X-ray absorptiometry (DXA) of the lumbar spine in a clinical pediatric setting: does the method of size adjustment matter?. Bone. 2005;37:413–419
  99. Carter DR, Bouxsein ML, Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res. 1992;7:137–145
  100. Kroger H, Kotaniemi A, Kroger L, et al. Development of bone mass and bone density of the spine and femoral neck — a prospective study of 65 children and adolescents. Bone Miner. 1993;23:171–182
  101. Katzman DK, Bachrach LK, Carter DR, et al. Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab. 1991;73:1332–1339
  102. Prentice A, Parsons T, Cole T. Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr. 1994;60:837–842
  103. Cole JH, Scerpella TA, van der Meulen MCH. Fan-beam densitometry of the growing skeleton. J Clin Densitom. 2005;8:57–64
  104. Wren TA, Liu X, Pitukcheewanont P, Gilsanz V. Bone densitometry in pediatric populations: discrepancies in the diagnosis of osteoporosis by DXA and CT. J Pediatr. 2005;146:776–779
  105. Pitukcheewanont P, Safani D, Church J, et al. Bone measures in HIV-1 infected children and adolescents: disparity between quantitative computed tomography and dual-energy X-ray absorptiometry measurements. Osteoporos Int. 2005;16:1393–1396
  106. Ahmed SF, Russell S, Rachid R, et al. Bone mineral content corrected for height or bone area, measured by DXA is not reduced in children with chronic renal disease or in hypoparathyroidism. Pediatr Nephrol. 2005;20:1466–1472
  107. Leonard MB, Shults J, Elliott DM, et al. Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography. Bone. 2004;34:1044–1052
  108. Kulack CA, Bilezikian JP. Bone mass measurement in identification of women at risk for osteoporosis. Int J Fertil Womens Med. 1999;44:269–278
  109. Leonard MB, Shults J, Wilson BA, et al. Obesity during childhood and adolescence augments bone mass and bone dimensions. Am J Clin Nutr. 2004;80(2):514–523
  110. Pludowski P, Lebiedowski M, Lorenc RS. Evaluation of the possibility to assess bone age on the basis of DXA derived hand scans- preliminary results. Osteoporos Int. 2004;15:317–322
  111. Pludowski P, Lebiedowski M, Lorenc RS. Evaluation of practical use of bone age assessments based on DXA-derived hand scans in diagnosis of skeletal status in healthy and diseased children. J Clin Densitom. 2005;8:48–56
  112. Greulich WW, Pyle SI. Radiographic Atlas of Skeletal Development of the Hand and Wrist. Palo AHO, CA: Stanford University Press; 1950;
  113. Tanner J, Healy M, Goldstein H, et al. Assessment of Skeletal Maturity and Prediction of Adult Height (TW3) Method. London: WB Saunders; 2001;
  114. Glastre C, Braillon P, David L, et al. Measurement of bone mineral content of the lumbar spine by dual-energy X-ray absorptiometry in normal children: correlations with growth parameters. J Clin Endocrinol Metab. 1990;70:1330–1333
  115. Zemel B, Kalkwarf H, Leonard M, et al. Effects of skeletal and sexual maturation on trabecular and cortical density of the peripheral skeleton. J Bone Miner Res. 2005;20:S59
  116. Mora S, Boechat MI, Peitka E, et al. Skeletal age determinations in children of European and African descent: applicability of the Greulich and Pyle standards. Pediatr Res. 2001;50:624–628
  117. Zemel B, Mahboubi S, Kalkwarf H, et al. Bone age deviates from chronological age in contemporary US children. J Bone Miner Res. 2006;21:S21
  118. Beunen GP, Malina RM, Lefevre JA, et al. Adiposity and biological maturity in girls 6–16 years of age. Int J Obes Relat Metab Disord. 1994;18:542–546
  119. Semeao EJ, Jawad AF, Stouffer NO, et al. Risk factors for low bone mineral density in children and young adults with Crohn's disease. J Pediatr. 1999;135:593–600
  120. Sabatier J-P, Guaydier-Souquieres G, Laroche D, et al. Bone mineral acquisition during adolescence and early adulthood: a study in 574 healthy females 10-24 years of age. Osteoporos Int. 1996;6:141–148
  121. Gilsanz V, Skaggs DL, Kovanlakaya A, et al. Differential effect of race on the axial and appendicular skeletons of children. J Clin Endocrinol Metab. 1998;83:1420–1427
  122. Molgaard C, Thomsen BL, Michaelsen KF. Influence of weight, age and puberty on bone size and bone mineral content in healthy children and adolescents. Acta Paediatr. 1998;87:494–499
  123. Desmangles JC, Lappe JM, Lipaczewski G, Haynatski G. Accuracy of pubertal Tanner staging self-reporting. J Pediatr Endocrinol Metab. 2006;19:213–221
  124. Duke PM, Litt IF, Gross RT. Adolescents' self assessment of sexual maturation. Pediatrics. 1980;66:918–920
  125. Morris NM, Udry JR. Validation of a self-administered instrument to assess stage of adolescent development. J Youth Adolesc. 1980;9:271–280
  126. Saland JM, Good ML, Haas DL, et al. The prevalence of osteopenia in pediatric renal allograft recipients varies with the method of analysis. Am J Transplant. 2001;1:243–250
  127. Young D, Hopper JL, Macinnis RJ, et al. Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26 years-old-female twins. Osteoporos Int. 2001;12:506–515
  128. Ogle GD, Allen JR, Humphries IR, et al. Body-composition assessment by dual-energy-X-ray absorptiometry in subjects aged 4-26 y. Am J Clin Nutr. 1995;61:746–753
  129. Ferrati JL, Cappozza RF, Cointry GR, et al. Gender-related differences in the relationship between densitometric values of whole-body bone mineral content and lean body mass in humans between 2 and 87 years of age. Bone. 1998;22:683–690
  130. Petit MA, Beck TJ, Kontulainen SA. Examining the developing bone: what do we measure and how do we do it?. J Musculoskelet Neuronal Interact. 2005;5:213–224
  131. Pludowski P, Karczmarewicz E, Socha J, et al. Skeletal and muscular status in GFD treated clinical and newly diagnosed atypical celiac disease- preliminary data. J Clin Densitom. 2007;10:76–85
  132. Zemel BS, Evaluation Petit M. In:  Sawyer AE,  Bachrach LK,  Fung EB editor. Bone Densitometry in Growing Patients. Totowa, NJ: Humana; 2007;p. 117
  133. Hastie T, Tibshirani R. Generalized Additive Models. New York, NY: Chapman and Hall,; 1990;
  134. Bachrach LK, Hastie T, Wang M-C, et al. Bone mineral acquisition in healthy Asian, Hispanic, Black and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab. 1999;84:4702–4712
  135. Cole TJ, Green PJ. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med. 1992;11:1305–1319
  136. Leonard MB, Propert KJ, Zemel BS, et al. Discrepancies in pediatric bone mineral density reference data: potential for misdiagnosis of osteopenia. J Pediatr. 1999;135:182–188
  137. Leonard MB, Feldman HI, Zemel BS, et al. Evaluation of low density spine software for the assessment of bone mineral density in children. J Bone Miner Res. 1998;13:1687–1690
  138. Shypailo RJ, Ellis KJ. Bone assessment in children: comparison of fan-beam DXA analysis. J Clin Densitom. 2005;8(4):445–453
  139. Genant HK, Grampp S, Gluer CC, et al. Universal standardization for dual X-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res. 1994;9:1503–1510
  140. Faulkner RA, Bailey DA, Drinkwater DT, et al. Regional and total body bone mineral content, bone mineral density, and total body tissue composition in children 8-16 years of age. Calcif Tissue Int. 1993;53:7–12
  141. Faulkner RA, Bailey DA, Drinkwater DT, McKay HA, Arnold C, Wilkinson AA. Bone densitometry in Canadian children 8–17 years of age. Calcif Tissue Int. 1996;59:344–351
  142. Binkley TL, Specker BL, Wittig TA. Centile curves for bone density measurements in healthy males and females ages 5–22 yr. J Clin Densitom. 2002;5:343–353
  143. Kelly TL, Specker BL, Binkley T, et al. Pediatric BMD reference database for US white children. Bone. 2005;36(suppl 1):S30
  144. Lu PW, Cowell CT, Lloyd-Jones SA, et al. Volumetric bone density in normal subjects, aged 5–27 years. J Clin Endocrinol Metals. 1996;81:1586–1590
  145. Del Rio L, Carrascosa F, Pons M, et al. Bone mineral density of the lumbar spine in white Mediterranean Spanish children and adolescents: changes related to age, sex, and puberty. Pediatr Res. 1994;35:362–366
  146. Boot AM, de Ridder MA, Pols HA, et al. Bone mineral density in children and adolescents: relation to puberty, calcium intake, and physical activity. J Clin Endocrinol Metab. 1997;82(1):57–62
  147. Fonseca ASM, Szeinfeld VI, Terren MT, et al. Bone mineral density of the lumbar spine of Brazilian children and adolescents aged 6–14 years. Braz J Med Biol Res. 2001;34:347–352
  148. Cheng JCY, Leung SSSF, Lee WTK, et al. Determinants of axial and peripheral bone mass in Chinese adolescents. Arch Dis Child. 1998;78:524–530
  149. Goksen D, Darcan S, Coker M, et al. Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom. 2006;9(1):84–90
  150. Hasanoglu A, Tumer L, Ezgu FS. Vertebra and femur bone mineral density values in Turkish children. Turk J Pediatr. 2004;46:298–302
  151. Pludowski P, Matusik H, Olszaniecka M, et al. Reference values for the indicators of skeletal and muscular status of healthy Polish children. J Clin Densitom. 2005;8(2):164–177
  152. Sala A, Webber CE, Morrison J, et al. Whole-body bone mineral content, lean body mass, and fat mass as measured by dual-energy X-ray absorptiometry in a population of healthy Canadian children and adolescents. Can Assoc Radiol J. 2007;58(1):46–52
  153. Webber CE, Baeaumon LF, Morrison J, et al. Age-predicted values for lumbar spine, proximal femur, and whole-body bone mineral density: results from a population of normal children age 3-18 years. Can Assoc Radiol J. 2007;58(1):37–45
  154. van der Sluis IM, de Ridder MA, Boot AM, et al. Reference data for bone density and body composition measured with dual energy X-ray absorptiometry in white children and young adults. Arch Dis Child. 2002;87:341–347
  155. Crabtree NJ, Oldroyal B, Truscott JG, et al. UK paediatric DXA reference data (GE Lunar Prodigy): effects of ethnicity, gender, and pubertal status. Bone. 2005;36:S42
  156. Zanchetta JR, Plotkin H, Alvarez Filguerira ML. Bone mass in children: normative values for the 2-20 year old population. Bone. 1995;16:393S–399S
  157. Fung EB, Bachrach LK, Briody JN, et al. Reporting DXA results. In: Bone Densitometry in Growing Patients. Sawyer AE, Bachrach LK, Fung EB, ed. Totowa, NJ: Humana Press, 129–130.

PII: S1094-6950(07)00253-3

doi: 10.1016/j.jocd.2007.12.005

Journal of Clinical Densitometry
Volume 11, Issue 1 , Pages 43-58 , January 2008

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