Journal of Clinical Densitometry
Volume 10, Issue 4 , Pages 395-403 , October 2007

Relationship of Circulating Total Homocysteine and C-Reactive Protein to Trabecular Bone in Postmenopausal Women

  • Shilpa N. Bhupathiraju

      Affiliations

    • Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA, USA
    • ,
  • D. Lee Alekel

      Affiliations

    • Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA, USA
    • Corresponding Author InformationAddress correspondence to: Dr. D. Lee Alekel, PhD, Iowa State University, Center for Designing Foods to Improve Nutrition, Food Science and Human Nutrition, Human Metabolic Unit, Ames, IA 50011, USA.
    • ,
  • Jeanne W. Stewart

      Affiliations

    • Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA, USA
    • ,
  • Laura N. Hanson

      Affiliations

    • Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA, USA
    • ,
  • Kristine M. Shedd

      Affiliations

    • USDA ARS, WHNRC University of California, Davis, CA, USA
    • ,
  • Manju B. Reddy

      Affiliations

    • Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA, USA
    • ,
  • Kathy B. Hanson

      Affiliations

    • Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA, USA
    • ,
  • Marta D. Van Loan

      Affiliations

    • USDA ARS, WHNRC University of California, Davis, CA, USA
    • ,
  • Ulrike Genschel

      Affiliations

    • Department of Statistics, Iowa State University, Ames, IA, USA
    • ,
  • Kenneth J. Koehler

      Affiliations

    • Department of Statistics, Iowa State University, Ames, IA, USA

Received 15 March 2007 ,Revised 30 May 2007 ,Accepted 12 June 2007.

References 

  1. Centers for Disease Control & Prevention . Available at: http://www.cdc.gov/reproductivehealth/WomensRH/Menopause.htmAccessed May 24, 2007
  2. Gerdhem P, Ivaska KK, Isaksson A, et al. Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J Bone Miner Res. 2007;22:127–134
  3. Gjesdal CG, Vollset SE, Ueland PM, et al. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med. 2006;166:88–94
  4. McLean RR, Jacques PF, Selhub J, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004;350:2042–2049
  5. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004;350:2033–2041
  6. Ganji V, Kafai MR. Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: analysis of data from National Health and Nutrition Examination Surveys, 1988–1994, 1999–2000, and 2001–2002. J Nutr. 2006;136:153–158
  7. Hak AE, Polderman KH, Westendorp IC, et al. Increased plasma homocysteine after menopause. Atherosclerosis. 2000;149:163–168
  8. Hong X, Hsu YH, Terwedow H, et al. Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women. Bone. 2007;40:737–742
  9. Kim DJ, Park BL, Koh JM, et al. Methionine synthase reductase polymorphisms are associated with serum osteocalcin levels in postmenopausal women. Exp Mol Med. 2006;38:519–524
  10. Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol. 2004;29(8):439–493
  11. Takagi Y, Fujii Y, Miyauchi A, Goto B, Takahashi K, Fujita T. Transmenopausal change of trabecular bone density and structural pattern assessed by peripheral quantitative computed tomography in Japanese women. J Bone Miner Res. 1995;10:1830–1840
  12. Grampp S, Lang P, Jergas M, et al. Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: short-term precision in vivo and comparison to DXA. J Bone Miner Res. 1995;10:1566–1576
  13. Ebbesen EN, Thomsen JS, Mosekilde L. Nondestructive determination of iliac crest cancellous bone strength by pQCT. Bone. 1997;21:535–540
  14. Sievanen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I. Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision. J Bone Miner Res. 1998;13:871–882
  15. Rauch F, Klein K, Allolio B, Schonau E. Age at menarche and cortical bone geometry in premenopausal women. Bone. 1999;25:69–73
  16. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 1987;422:43–52
  17. Ubbink JB, Vermaak WJH, Bissbort S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr. 1991;565:441–446
  18. Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics. 1982;38:963–974
  19. Pearson TA, Mensah GA, Alexander RW, et al. Centers for Disease Control and Prevention American Heart Association Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  20. Allison PD. Logistic regression using the SAS system: theory and application. Cary, NC: SAS Institute Inc.; 1999;
  21. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus . Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26:3160–3167
  22. Koh JM, Khang YH, Jung CH, et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int. 2005;16:1263–1271
  23. Scheiber MD, Rebar RW. Isoflavones and postmenopausal bone health: a viable alternative to estrogen therapy?. Menopause. 1999;6:233–241
  24. Welty FK. Women and cardiovascular risk. Am J Cardiol. 2001;88:48J–52J
  25. Baines M, Kredan MB, Usher J, et al. The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women. Bone. 2007;40:730–736
  26. Cesari M, Pahor M, Lauretani F, et al. Bone density and hemoglobin levels in older persons: results from the InCHIANTI study. Osteoporos Int. 2005;16:691–699
  27. Parelman M, Stoecker B, Baker A, Medeiros D. Iron restriction negatively affects bone in female rats and mineralization of hFOB osteoblast cells. Exp Biol Med (Maywood). 2006;231:378–386
  28. Medeiros DM, Stoecker B, Plattner A, Jennings D, Haub M. Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight. J Nutr. 2004;134:3061–3067
  29. Tuderman L, Myllyla R, Kivirikko KI. Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates. Eur J Biochem. 1977;80:341–348
  30. Pietschmann F, Breslau NA, Pak CY. Reduced vertebral bone density in hypercalciuric nephrolithiasis. J Bone Miner Res. 1992;7:1383–1388
  31. Guglielmi G, van Kuijk C, Li J, Meta MD, Scillitani A, Lang TF. Influence of anthropometric parameters and bone size on bone mineral density using volumetric quantitative computed tomography and dual X-ray absorptiometry at the hip. Acta Radiol. 2006;47:574–580
  32. Bakri Hassan A, Ronnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I. Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease. J Autoimmun. 1998;11:503–508
  33. Haugeberg G, Green MJ, Quinn MA, et al. Hand bone loss in early undifferentiated arthritis. Evaluating BMD loss before the development of rheumatoid arthritis. Ann Rheum Dis. 2006;65:736–740
  34. Punzi L, Ramonda R, Oliviero F, et al. Value of C reactive protein in the assessment of erosive osteoarthritis of the hand. Ann Rheum Dis. 2005;64:955–957
  35. Rifai N, Ridker PM. Population distributions of C-reactive protein in apparently healthy men and women in the United States: implication for clinical interpretation. Clin Chem. 2003;49:666–669
  36. Ganji V, Kafai MR, Third National Health and Nutrition Examination Survey . Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr. 2003;77:826–833
  37. Merck Manual of Diagnosis and Therapy. 17th ed.. Whitehouse Station, NJ: Merck Research Laboratories; 1999;
  38. Hummel M, Buchheidt D, Reiter S, Bergmann J, Hofheinz R, Hehlmann R. Successful treatment of hyperuricemia with low doses of recombinant urate oxidase in four patients with hematologic malignancy and tumor lysis syndrome. Leukemia. 2003;17:2542–2544

PII: S1094-6950(07)00179-5

doi: 10.1016/j.jocd.2007.06.002

Journal of Clinical Densitometry
Volume 10, Issue 4 , Pages 395-403 , October 2007

Article Tools

* Image Usage & Resolution