Journal of Clinical Densitometry
Volume 10, Issue 1 , Pages 34-38 , January 2007

Effect of Bone Strontium on BMD Measurements

  • Glen M. Blake

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Dr. G. M. Blake, Ph.D., Department of Nuclear Medicine, Guy's Hospital, King's College London School of Medicine, St Thomas Street, London SE1 9RT, United Kingdom.
    • ,
  • Ignac Fogelman

Received 31 July 2006 ,Accepted 9 October 2006.

References 

  1. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis—a 2-year randomised placebo controlled trial. J Clin Endocrinol Metab. 2002;87:2060–2066
  2. Reginster JY, Deroisy R, Dougados M, Jupsin I, Colette J, Roux C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomised, two-year, double-masked, dose ranging, placebo-controlled PREVOS trial. Osteoporos Int. 2002;13:925–931
  3. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004;350:459–468
  4. Reginster J-Y, Seeman E, De Vernejoul MC, et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab. 2005;90:2816–2822
  5. Roux C, Reginster JY, Fechtenbaum J, et al. Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors. J Bone Miner Res. 2006;21:536–542
  6. Seeman E, Vellas B, Benhamou C, et al. Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older. J Bone Miner Res. 2006;21:1113–1120
  7. Liberman UA, Weiss SR, Broll J, et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med. 1995;333:1437–1443
  8. Black DM, Cummings SR, Karpf DB, et al. Randomised trial of the effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet. 1996;348:1535–1541
  9. Harris ST, Watts NB, Genant HK, et al. Effects of risedronate treatment on vertebral and non-vertebral fractures in women with postmenopausal osteoporosis. JAMA. 1999;282:1344–1352
  10. Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomised clinical trial. JAMA. 1999;282:637–645
  11. Blake GM, Fogelman I. Long-term effect of strontium ranelate treatment on BMD. J Bone Miner Res. 2005;20:1901–1904
  12. Pors Nielsen S, Slosman D, Sorensen OH, et al. Influence of strontium on bone mineral density and bone mineral content measurements by dual x-ray absorptiometry. J Clin Densitom. 1999;2:371–379
  13. Blake GM. 1999 Commercial instruments for x-ray absorptiometry of the peripheral skeleton. In: The Evaluation of Osteoporosis: Dual Energy X-Ray Absorptiometry and Ultrasound in Clinical Practice. Blake GM, Wahner HW, and Ignac Fogelman, eds. London, UK: Martin Dunitz, 89–105.
  14. Guglielmi G, Lang TF. Quantitative computed tomography. Semin Musculoskelet Radiol. 2002;6:219–227
  15. Hubbell JH, Seltzer SM. Tables of x-ray mass attenuation coefficients and mass energy absorption coefficients. Available at: http://physics.nist.gov/PhysRefData/XrayMassCoef/cover.htmlAccessed July 28, 2006
  16. Blake GM, Fogelman I. Technical principles of dual energy x-ray absorptiometry. Semin Nucl Med. 1997;27:210–228
  17. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S12911) administration. J Bone Miner Res. 1996;11:1302–1311
  18. Farlay D, Boivin G, Pranczer G, Alande A, Meunier PJ. Long term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone. J Bone Miner Res. 2005;20:1569–1578
  19. Peel NF, Eastell R. Comparison of rates of bone loss from the spine measured using two manufacturers' densitometers. J Bone Miner Res. 1995;10:1796–1801
  20. Blake GM, Fogelman I. A theoretical model for the interpretation of bone density scans in patients stopping strontium ranelate treatment. J Bone Miner Res. 2006;21:1417–1424
  21. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone. 2001;28:446–453

PII: S1094-6950(06)00263-0

doi: 10.1016/j.jocd.2006.10.004

Journal of Clinical Densitometry
Volume 10, Issue 1 , Pages 34-38 , January 2007

Article Tools

* Image Usage & Resolution