Journal of Clinical Densitometry
Volume 9, Issue 2 , Pages 167-174 , April 2006

Pamidronate Treatment and Posttreatment Bone Density in Children With Spastic Quadriplegic Cerebral Palsy

  • Steven J. Bachrach

      Affiliations

    • Department of Pediatrics, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, DE
    • ,
  • Heidi H. Kecskemethy

      Affiliations

    • Nemours Biomedical Research, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, DE
    • ,
  • H. Theodore Harcke

      Affiliations

    • Department of Medical Imaging, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, DE
    • Corresponding Author InformationAddress correspondence to H. Theodore Harcke, MD, Department of Medical Imaging, Alfred I. duPont Hospital for Children, P.O. Box 269, Wilmington, DE 19899.
    • ,
  • Robert K. Lark

      Affiliations

    • Department of Orthopedics, University of North Carolina, Chapel Hill, NC
    • ,
  • Freeman Miller

      Affiliations

    • Department of Orthopaedics, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, DE
    • ,
  • Richard C. Henderson

      Affiliations

    • Department of Orthopedics, University of North Carolina, Chapel Hill, NC
    • Department of Pediatrics, University of North Carolina, Chapel Hill, NC

Received 21 September 2005 ,Revised 15 November 2005 ,Accepted 15 November 2005.

References 

  1. Henderson RC, Lin PP, Greene WB. Bone mineral density in children and adolescents who have spastic cerebral palsy. J Bone Joint Surg Am. 1995;77:1671–1681
  2. Henderson RC. Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia. Dev Med Child Neurol. 1997;39:224–227
  3. Henderson RC, Lark RK, Gurka MJ, et al. Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy. Pediatrics. 2002;110(1 Pt 1):e5
  4. Hahn TJ, Halstead LR. Anticonvulsant drug-induced osteomalacia: alterations in mineral metabolism and response to vitamin D3 administration. Calcif Tissue Int. 1979;27:13–18
  5. Lee JJ, Lyne ED. Pathologic fractures in severely handicapped children and young adults. J Pediatr Orthop. 1990;10:497–500
  6. Shaw NJ, White CP, Fraser WD, Rosenbloom L. Osteopenia in cerebral palsy. Arch Dis Child. 1994;71:235–238
  7. Glorieux FH, Bishop NJ, Plotkin H, Chabot G, Lanoue G, Travers R. Cyclic administration of pamidronate in children with severe osteogenesis imperfecta. N Engl J Med. 1998;339:947–952
  8. Falk MJ, Heeger S, Lynch KA, et al. Intravenous bisphosphonate therapy in children with osteogenesis imperfecta. Pediatrics. 2003;111:573–578
  9. Rauch F, Plotkin H, Zeitlin L, Glorieux FH. Bone mass, size, and density in children and adolescents with osteogenesis imperfecta: effect of intravenous pamidronate therapy. J Bone Miner Res. 2003;18:610–614
  10. Steelman J, Zeitler P. Treatment of symptomatic pediatric osteoporosis with cyclic single-day intravenous pamidronate infusions. J Pediatr. 2003;142:417–423
  11. Henderson RC, Lark RK, Kecskemethy HH, Miller F, Harcke HT, Bachrach SJ. Bisphosphonates to treat osteopenia in children with quadriplegic cerebral palsy: a randomized, placebo-controlled clinical trial. J Pediatr. 2002;141:644–651
  12. Grissom LE, Kecskemethy HH, Bachrach SJ, McKay C, Harcke HT. Bone densitometry in pediatric patients treated with pamidronate. Pediatr Radiol. 2005;35:511–517
  13. Lin JH. Bisphosphonates: a review of their pharmacokinetic properties. Bone. 1996;18:75–85
  14. Harcke HT, Taylor A, Bachrach S, Miller F, Henderson RC. Lateral femoral scan: an alternative method for assessing bone mineral density in children with cerebral palsy. Pediatr Radiol. 1998;28:241–246
  15. Henderson RC, Lark RK, Newman JE, et al. Pediatric reference data for dual X-ray absorptiometric measures of normal bone density in the distal femur. AJR Am J Roentgenol. 2002;178:439–443
  16. Henderson RC, Kairalla JA, Barrington JW, Abbas A, Stevenson RD. Longitudinal changes in bone density in children and adolescents with moderate to severe cerebral palsy. J Pediatr. 2005;146:769–775
  17. Rauch F, Travers R, Plotkin H, Glorieux FH. The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta. J Clin Invest. 2002;110:1293–1299
  18. Grissom LE, Harcke HT. Radiographic features of bisphosphonate therapy in pediatric patients. Pediatr Radiol. 2003;33:226–229
  19. Rauch F, Travers R, Munns C, Glorieux FH. Sclerotic metaphyseal lines in a child treated with pamidronate: histomorphometric analysis. J Bone Miner Res. 2004;19:1191–1193
  20. Brumsen C, Hamdy NA, Papapoulos SE. Long-term effects of bisphosphonates on the growing skeleton. Studies of young patients with severe osteoporosis. Medicine (Baltimore). 1997;76:266–283
  21. Whyte MP, Wenkert D, Clements KL, McAlister WH, Mumm S. Bisphosphonate-induced osteopetrosis. N Engl J Med. 2003;349:457–463

PII: S1094-6950(06)00010-2

doi: 10.1016/j.jocd.2005.11.003

Journal of Clinical Densitometry
Volume 9, Issue 2 , Pages 167-174 , April 2006

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