Journal of Clinical Densitometry
Volume 9, Issue 1 , Pages 78-83, January 2006

Densitometric and Quantitative Ultrasound Measurements and Laboratory Investigations in Wheelchair-Bound Patients

  • Wojciech Pluskiewicz

      Affiliations

    • Department and Clinic of Internal Diseases, Diabetology and Nephrology, Metabolic Bone Disease Unit, Zabrze, Poland
    • Corresponding Author InformationAddress correspondence to: Wojciech Pluskiewicz, MD, PhD, Metabolic Bone Diseases Unit, 3 Maja 13/15 Str., 41-800 Zabrze, Poland.
    • ,
  • Bogna Drozdzowska

      Affiliations

    • Department and Chair of Pathomorphology, Zabrze, Poland
    • ,
  • Anita Lyssek-Boroń

      Affiliations

    • Department and Clinic of Ophtalmology, Sosnowiec, Poland
    • ,
  • Tomasz Bielecki

      Affiliations

    • Department and Clinic of Orthopaedics, Sosnowiec, Poland
    • ,
  • Piotr Adamczyk

      Affiliations

    • Department and Clinic of Pediatrics, Pediatric Nephrology, and Endocrinology, Zabrze, Poland
    • ,
  • Przemysław Sawaryn

      Affiliations

    • Nursing Home for Disabled Subjects, Mikołów, Poland
    • ,
  • Maciej Misolek

      Affiliations

    • Department of E N T, Zabrze, Poland
    • ,
  • 1–5,7Silesian School of Medicine in Katowice, Poland

Received 22 June 2005; received in revised form 28 September 2005; accepted 28 September 2005.

Abstract 

Skeletal status and laboratory investigations may be influenced by immobilization. Thirty-six wheelchair-bound subjects and 19 age-matched controls were evaluated using measurements of bone mineral density (BMD) at the calcaneus and forearm (PIXI, Madison, WI), amplitude-dependent speed of sound at the hand phalanges (quantitative ultrasound-DBM Sonic 1200, IGEA, Modena, Italy), carboxyterminal telopeptide of type I collagen and bone alkaline phosphatase. In the whole group and in the males, bone mineral density values were significantly lower in comparison with controls (calcaneus, forearm) and in females only for calcaneus. The duration of the disease significantly influenced the calcaneal bone mineral density data. Bone alkaline phosphatase was significantly lower in the patients than in the controls. Bone resorption had a negative influence on forearm BMD. Generally, skeletal and laboratory results were not affected by duration of the disease or reason for immobilization. In conclusion, in wheelchair-bound subjects, the skeletal status was affected and bone formation was depressed.

Key Words: Amplitude-dependent speed of sound, bone alkaline phosphatase, bone mineral density, cerebral palsy, collagen, immobilization

 

PII: S1094-6950(06)00005-9

doi:10.1016/j.jocd.2005.09.001

Journal of Clinical Densitometry
Volume 9, Issue 1 , Pages 78-83, January 2006

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